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Type: Artigo de periódico
Title: Opposite Effects Of Mn(iii) And Fe(iii) Forms Of Meso-tetrakis(4-n-methyl Pyridiniumyl) Porphyrins On Isolated Rat Liver Mitochondria.
Author: Nepomuceno, M F
Tabak, M
Vercesi, A E
Abstract: The relevance of porphyrins as therapeutic drugs targeted to mitochondria has been widely recognized. In this work, we studied the action of meso-tetrakis porphyrins (TMPyP) on respiring rat liver mitochondria. Mn(III)TMPyP exerted a protective effect against lipid peroxidation induced by Fe(II) or the azo initiator 4,4'-azobis(4-cyanopentanoic acid) (ABCPA), which partition in the hydrophobic phospholipid moiety, and 2,2'-azobis(2-amidinepropane)dihydrochloride (ABAP), which partitions in the aqueous phase. In contrast, Fe(III)TMPyP itself induced an intense lipid peroxidation, accompanied by mitochondrial permeability transition. Both mesoporphyrins studied promoted a release of mitochondrial state-4 respiration, in the concentration range of 1.0-20 microM. Based on the relative effects of Mn(III)TMPyP against ABAP and ABCPA-induced lipid peroxidation, we believe that meso-tetrakis porphyrins must concentrate preferably at membrane-water interfaces.
Subject: Animals
Dose-response Relationship, Drug
Intracellular Membranes
Lipid Peroxidation
Mitochondria, Liver
Oxidative Phosphorylation
Oxygen Consumption
Rats, Wistar
Citation: Journal Of Bioenergetics And Biomembranes. v. 34, n. 1, p. 41-7, 2002-Feb.
Rights: fechado
Identifier DOI: 
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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