Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195264
Type: Artigo de periódico
Title: No Association Of The 5' Promoter Region Polymorphism Of Cyp17 Gene With Prostate Cancer Risk.
Author: dos Santos, A
Ribeiro, M L
Mesquita, J C
Carvalho-Salles, A B
Hackel, C
Abstract: CYP17 gene encodes the enzyme cytochrome p450c17alpha, which mediates two steps in the steroid biosynthesis pathway. Steroid hormones are believed to play a key role in the etiology of prostate cancer. A polymorphic T-->C transition in the 5(') promoter region of CYP17 creates an additional Sp1-type (CCACC box) promoter site (allele A2). We have evaluated the genotypic and allelic distribution of this polymorphism among 92 prostate cancer patients in order to assess risk by comparison with a population-based series of 200 healthy individuals from Brazil. Our results provide no evidence for an association between prostate cancer risk and CYP17 T/C polymorphism.
Subject: Adult
Aged
Brazil
Case-control Studies
Gene Frequency
Genetic Predisposition To Disease
Genotype
Humans
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Promoter Regions, Genetic
Prostate
Prostatic Neoplasms
Risk Factors
Steroid 17-alpha-hydroxylase
Rights: fechado
Identifier DOI: 10.1038/sj.pcan.4500550
Address: http://www.ncbi.nlm.nih.gov/pubmed/15195127
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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