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Type: Artigo de periódico
Title: Evaluation Of The Antiedematogenic Activity Of Artemetin Isolated From Cordia Curassavica Dc.
Author: Bayeux, M C
Fernandes, A T
Foglio, M A
Carvalho, J E
Abstract: The species Cordia curassavica (Boraginaceae), known popularly as erva baleeira, is used in folk medicine for the treatment of several inflammatory processes and as a healing agent. The objective of the present study was to evaluate the antiedematogenic activity of crude dichloromethane extracts of Cordia curassavica and of the artemetin-enriched fraction. The crude extract and artemetin fraction were tested in the model of carrageenin-induced paw edema in male Swiss mice (25-30 g). The crude dichloromethane extract (300 and 1000 mg/kg, po, N = 6) showed significant antiedematogenic activity, reducing the edema by 42, 57 and 45% and 46, 62 and 69%, 3, 4 and 5 h after carrageenin administration, respectively. Indomethacin (10 mg/kg, po, N = 6) reduced the edema by 45 and 48%, after 4 and 5 h, but the artemetin-enriched fraction (30, 100 and 300 mg/kg, po, N = 6) had no activity. The dichloromethane extract (300 and 1000 mg/kg, po, N = 6) also showed antinociceptive activity by reducing acetic acid-induced writhing in mice from 37.1 +/- 2.28 (control) to 17.3 +/- 1.34 and 13.2 +/- 1.44, respectively, but had no activity in the hot-plate test.
Subject: Animals
Anti-inflammatory Agents
Drug Evaluation, Preclinical
Medicine, Traditional
Methylene Chloride
Plant Extracts
Rights: aberto
Identifier DOI: 
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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