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Type: Artigo de periódico
Title: Mutations In The P53 Gene In Acute Myeloid Leukemia Patients Correlate With Poor Prognosis.
Author: Melo, Mônica B
Ahmad, Nilofer N
Lima, Carmen S P
Pagnano, Katia B B
Bordin, Silvana
Lorand-Metze, Irene
SaAd, Sara T O
Costa, Fernando F
Abstract: Inactivation of tumor suppressor genes, whose products exert an inhibitory influence on cell cycle progression, can lead to neoplastic transformation. In acute myeloid leukemia (AML), the frequency of p53 gene mutations ranges from 4 to 15% in populations from USA and Europe. In an attempt to investigate the frequency of point mutations in the p53 gene in AML Brazilian patients, DNA samples of 35 patients were studied using PCR-SSCP techniques, screening exons 4-10. Mutations were identified in bone marrow DNA in 5 of the 35 AML patients (14.3%), a frequency similar to those reported for Northern American and European populations. The overall survival of patients with mutations in the p53 gene was significantly shorter than for patients without mutations.
Subject: Acute Disease
Bone Marrow
Dna Mutational Analysis
Gene Frequency
Genes, P53
Leukemia, Myeloid
Survival Analysis
Citation: Hematology (amsterdam, Netherlands). v. 7, n. 1, p. 13-9, 2002-Feb.
Rights: fechado
Identifier DOI: 10.1080/10245330290020090
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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