Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195062
Type: Artigo de periódico
Title: Modulation By Acanthospermum Australe Extracts Of The Tumor Induced Hematopoietic Changes In Mice.
Author: Mirandola, Luciana
Justo, Giselle Z
Queiroz, Mary L S
Abstract: Previous studies on the Ehrlich ascites tumor (EAT) model indicate that tumor progression is associated with reduced myelopoiesis and increased extramedullar hematopoiesis. In order to investigate the in vivo antitumor activity of Acanthospermum australe, its hydroalcoholic extract was partitioned with different solvents and the resulting extracts were monitored by their effects on bone marrow and spleen hematopoietic progenitor cell proliferation and differentiation in EAT-bearing mice. Oral treatment of tumor-bearing mice with 3 doses of 100, 500 and 1000 mg/kg of the crude hydroalcoholic extract and its chloroformic, butanolic and aqueous fractions significantly stimulated myelepoiesis and brought extramedullar hematopoiesis back to near control values. In normal mice, stimulation of myelopoiesis was only observed with the crude and the butanolic extracts. All the extracts at 500 mg/kg significantly increased survival of tumor-bearing mice, however a clear survival advantage in the group treated with the butanolic extract was observed. These results suggest that A. australe may exert effects on myelopoiesis that may be implicated in antitumor immune responses.
Subject: Animals
Antineoplastic Agents, Phytogenic
Asteraceae
Bone Marrow
Carcinoma, Ehrlich Tumor
Colony-forming Units Assay
Hematopoiesis
Male
Mice
Mice, Inbred Balb C
Myelopoiesis
Phytotherapy
Plant Extracts
Spleen
Rights: fechado
Identifier DOI: 10.1081/IPH-120003761
Address: http://www.ncbi.nlm.nih.gov/pubmed/12066853
Date Issue: 2002
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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