Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195054
Type: Artigo de periódico
Title: Biomarkers Predictive Of Lymph Node Metastases In Oral Squamous Cell Carcinoma.
Author: Lopes, Márcio Ajudarte
Nikitakis, Nikolaos G
Reynolds, Mark A
Ord, Robert A
Sauk, John
Abstract: The ability of oral squamous cell carcinoma to metastasize to lymph nodes does not always show a relationship with clinical staging. The aim of this study was to attempt to define a trend for predictive histopathologic and/or molecular biomarkers in the development of nodal metastasis by analyzing 2 clinically extreme groups. Patients with small primary tumors (T1, T2) with lymph node metastasis and patients with large primary tumors (T3, T4) without metastatic disease were identified among 315 consecutive cases of primary oral squamous cell carcinoma. Group comparisons were made with use of a Mann-Whitney test, and associations among the variables were assessed with nonparametric and parametric correlational analyses. The degree of keratinization was significantly less in primary tumors with lymph node metastasis (P < or = .01). The degree of keratinization was significantly associated with nuclear pleomorphism (P =.02), number of mitoses (P =.02), stage of invasion (P =.002), and p53 expression (P =.04), independent of clinical stage of the tumor. Other microscopic features and immunohistochemical markers did not differ significantly between the groups (P >.05). These data indicate that there still is no single predictive parameter superior to the degree of keratinization to identify patients at risk for the development of regional metastasis.
Subject: Adult
Aged
Biological Markers
Carcinoma, Squamous Cell
Cell Nucleus
Female
Forecasting
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Keratins
Lymphatic Metastasis
Male
Middle Aged
Mitosis
Mouth Neoplasms
Neoplasm Invasiveness
Neoplasm Staging
Proliferating Cell Nuclear Antigen
Proto-oncogene Proteins C-bcl-2
Receptor, Erbb-2
Risk Factors
Statistics As Topic
Statistics, Nonparametric
Tumor Suppressor Protein P53
Citation: Journal Of Oral And Maxillofacial Surgery : Official Journal Of The American Association Of Oral And Maxillofacial Surgeons. v. 60, n. 2, p. 142-7; discussion 147-8, 2002-Feb.
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11815908
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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