Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195051
Type: Artigo de periódico
Title: Participation Of The Mitochondrial Permeability Transition Pore In Nitric Oxide-induced Plant Cell Death.
Author: Saviani, Elzira E
Orsi, Cintia H
Oliveira, Jusceley F P
Pinto-Maglio, Cecília A F
Salgado, Ione
Abstract: In the present study, we investigated the involvement of the mitochondrial permeability transition pore (PTP) in nitric oxide (NO)-induced plant cell death. NO donors such as sodium nitroprusside (SNP) and S-nitroso-N-acetylpenicillamine inhibited growth and caused death in suspension-cultured cells of Citrus sinensis. Cells treated with SNP showed chromatin condensation and fragmentation, characteristic of apoptosis. SNP caused loss of the mitochondrial membrane electrical potential, which was prevented by cyclosporin A (CsA), a specific inhibitor of PTP formation. CsA also prevented the nuclear apoptosis and subsequent Citrus cell death induced by NO. These findings indicate that mitochondrial PTP formation is involved in the signaling pathway by which NO induces apoptosis in cultured Citrus cells.
Subject: Apoptosis
Cell Death
Cell Division
Cells, Cultured
Citrus
Cyclosporine
Dna Fragmentation
Intracellular Membranes
Ion Channels
Membrane Potentials
Membrane Proteins
Mitochondria
Mitochondrial Membrane Transport Proteins
Nitric Oxide
Nitric Oxide Donors
Nitroprusside
S-nitroso-n-acetylpenicillamine
Signal Transduction
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11801241
Date Issue: 2002
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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