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Type: Artigo de periódico
Title: Insulin Modulates Leptin-induced Stat3 Activation In Rat Hypothalamus.
Author: Carvalheira, J B
Siloto, R M
Ignacchitti, I
Brenelli, S L
Carvalho, C R
Leite, A
Velloso, L A
Gontijo, J A
Saad, M J
Abstract: Insulin and leptin have overlapping effects in the control of energy homeostasis, but the molecular basis of this synergism is unknown. Insulin signals through a receptor tyrosine kinase that phosphorylates and activates the docking proteins IRSs (insulin receptor substrates), whereas the leptin receptor and its associated protein tyrosine kinase JAK2 (Janus kinase 2) mediate phosphorylation and activation of the transcription factor STAT3 (signal transducer and activator of transcription). Here, we present evidence for the integration of leptin and insulin signals in the hypothalamus. Insulin induced JAK2 tyrosine phosphorylation, leptin receptor phosphorylation which, in the presence of leptin, augmented the interaction between STAT3 and this receptor. Insulin also increased the leptin-induced phosphorylation of STAT3 and its activation. These results indicate that insulin modulates the leptin signal transduction pathway, and may provide a molecular basis for the coordinated effects of insulin and leptin in feeding behavior and weight control.
Subject: Animals
Blotting, Western
Carrier Proteins
Dna-binding Proteins
Injections, Intraventricular
Janus Kinase 2
Models, Biological
Protein-tyrosine Kinases
Proto-oncogene Proteins
Rats, Wistar
Receptor, Insulin
Receptors, Cell Surface
Receptors, Leptin
Stat3 Transcription Factor
Signal Transduction
Citation: Febs Letters. v. 500, n. 3, p. 119-24, 2001-Jul.
Rights: fechado
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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