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Type: Artigo de periódico
Title: The Effect Of Cyclosporin A On The Activity Of Matrix Metalloproteinases During The Healing Of Rat Molar Extraction Wounds.
Author: Silva, H C
Coletta, R D
Jorge, J
Bolzani, G
de Almeida, O P
Graner, E
Abstract: Cyclosporin A (CyA) is a cyclic peptide used as an immunosuppressive agent because it can block the synthesis of interleukin-2 and other cytokines produced by CD4+ lymphocytes. It is widely used for the prevention of allograft rejection and treatment of autoimmune diseases. Several side-effects of CyA treatment have been reported, among which are chronic nephrotoxicity, hepatotoxicity and neurotoxicity, lymphoproliferative neoplasms, hypertension, thromboembolic complications and gingival overgrowth. Here, using a rat molar model, it is demonstrated that CyA immunosuppression inhibits the activity of matrix metalloproteinases 2 and 9 in the early phase of granulation tissue in the healing dental socket. These observations suggest that CyA may interfere with the wound healing following dental extractions.
Subject: Animals
Electrophoresis, Polyacrylamide Gel
Immunosuppressive Agents
Matrix Metalloproteinase Inhibitors
Random Allocation
Rats, Wistar
Tooth Extraction
Tooth Socket
Wound Healing
Rights: fechado
Identifier DOI: 
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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