Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/195024
Type: Artigo de periódico
Title: Molecular Morphogenetic Fields In The Development Of Human Dentition.
Author: Line, S R
Abstract: The mapping of the field of influence of specific regulatory molecules can provide a great deal of information on the molecular strategies that underlie the changes in the developmental program and macroevolutionary process. The strategy in this study was to use the variation in the number of teeth in the affected individuals of three mutant families with hypodontia, to determine the relative influence (relative molecular morphogenetic field) of MSX 1 and PAX 9 genes on the dental field. The variations in the pattern of symmetry of tooth agenesis were used in order to estimate the developmental stability of these genes. The approach used in the present work can help to explore new hypotheses linking development with the patterning of dentition during mammalian evolution. Furthermore, the developmental changes can be linked to changes in the molecular morphogenetic field of specific genes.
Subject: Anodontia
Biological Evolution
Dna-binding Proteins
Dentition
Homeodomain Proteins
Humans
Msx1 Transcription Factor
Morphogenesis
Mutation
Pax9 Transcription Factor
Transcription Factors
Rights: fechado
Identifier DOI: 10.1006/jtbi.2001.2333
Address: http://www.ncbi.nlm.nih.gov/pubmed/11407892
Date Issue: 2001
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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