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Type: Artigo de periódico
Title: Effects Of The Green Algae Chlorella Vulgaris On The Response Of The Host Hematopoietic System To Intraperitoneal Ehrlich Ascites Tumor Transplantation In Mice.
Author: Justo, G Z
Silva, M R
Queiroz, M L
Abstract: Chlorella vulgaris extract (CVE) was examined for its effects on the Ehrlich ascites tumor-induced suppression in the numbers of bone marrow and spleen granulocyte-macrophage progenitor cells (CFU-GM) in mice. No effects on bone marrow and spleen CFU-GM, as compared to controls, were observed in normal mice given 50, 100 and 200 mg/kg CVE orally for 5 days. In tumor-bearing mice, myelosuppression concomitant with increased number of spleen CFU-GM were observed. The number of CFU-GM in the bone marrow was restored to control levels after the administration of CVE (50, 100 and 200 mg/kg) to tumor-bearing mice, and a slight reduction in spleen colony formation was observed in these animals. In addition, CVE significantly prolonged the survival of mice inoculated with the Ehrlich ascites tumor. These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages.
Subject: Administration, Oral
Bone Marrow Cells
Carcinoma, Ehrlich Tumor
Cells, Cultured
Colony-forming Units Assay
Germ-free Life
Granulocyte-macrophage Colony-stimulating Factor
Hematopoiesis, Extramedullary
Hematopoietic Stem Cells
Injections, Intraperitoneal
Mice, Inbred Balb C
Neoplasm Transplantation
Plant Extracts
Recombinant Proteins
Survival Rate
Rights: fechado
Identifier DOI: 10.1081/IPH-100102573
Date Issue: 2001
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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