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Type: Artigo de periódico
Title: Cytosolic Thioredoxin Peroxidase I Is Essential For The Antioxidant Defense Of Yeast With Dysfunctional Mitochondria.
Author: Demasi, A P
Pereira, G A
Netto, L E
Abstract: The specific role of cytosolic thioredoxin peroxidase I (cTPx I), encoded by TSA1 (thiol-specific antioxidant), was investigated in the oxidative stress response of Saccharomyces cerevisiae. In most cases, deletion of TSA1 has showed only a slight effect on hydrogen peroxide sensitivity. However, when the functional state of the mitochondria was compromised, the necessity of TSA1 in cell protection against this oxidant was much more evident. All the procedures used to disrupt the mitochondrial respiratory chain promoted increases in the generation of H(2)O(2) in cells, which could be related to their elevated sensitivity to oxidative stress. In fact, TSA1 is highly expressed when cells with respiratory deficiency are exposed to H(2)O(2). In conclusion, our results indicate that cTPx I is a key component of the antioxidant defense in respiratory-deficient cells.
Subject: Antioxidants
Cell Division
Cell Respiration
Gene Expression Regulation, Fungal
Hydrogen Peroxide
Neoplasm Proteins
Oxidative Stress
Reactive Oxygen Species
Saccharomyces Cerevisiae
Transcription, Genetic
Rights: fechado
Identifier DOI: 
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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