Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194889
Type: Artigo de periódico
Title: Respiratory Chain Network In Mitochondria Of Candida Parapsilosis: Adp/o Appraisal Of The Multiple Electron Pathways.
Author: Milani, G
Jarmuszkiewicz, W
Sluse-Goffart, C M
Schreiber, A Z
Vercesi, A E
Sluse, F E
Abstract: In this study we demonstrated that mitochondria of Candida parapsilosis contain a constitutive ubiquinol alternative oxidase (AOX) in addition to a classical respiratory chain (CRC) and a parallel respiratory chain (PAR) both terminating by two different cytochrome c oxidases. The C. parapsilosis AOX is characterized by a fungi-type regulation by GMP (as a stimulator) and linoleic acid (as an inhibitor). Inhibitor screening of the respiratory network by the ADP/O ratio and state 3 respiration determinations showed that (i) oxygen can be reduced by the three terminal oxidases through four paths implying one bypass between CRC and PAR and (ii) the sum of CRC, AOX and PAR capacities is higher than the overall respiration (no additivity) and that their engagement could be progressive according to the redox state of ubiquinone, i.e. first cytochrome pathway, then AOX and finally PAR.
Subject: Adenosine Diphosphate
Candida
Cell Respiration
Cyanates
Electron Transport
Guanosine Monophosphate
Hydroxamic Acids
Linoleic Acid
Mitochondria
Mitochondrial Proteins
Nad
Oxidoreductases
Oxygen
Plant Proteins
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11718721
Date Issue: 2001
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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