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Type: Artigo de periódico
Title: Expression Of Inducible Nitric Oxide Synthase Is Increased In Acute Myeloid Leukaemia.
Author: Brandão, M M
Soares, E
Salles, T S
Saad, S T
Abstract: Significant activity of inducible nitric oxide synthase (iNOS) has been reported in tumour cells, including chronic lymphoid leukaemic cells. In this study, we analysed the expression of iNOS in 15 untreated patients with acute myeloid leukaemia (AML) and in 7 normal controls. Using flow cytometry and immunocytochemistry, we demonstrated that patients with AML had a high expression of iNOS when compared to controls. There was no correlation between the expression of iNOS and the expression of p53 and K, H, and N-ras mutation and expression, suggesting that the high expression of iNOS is independent of these proteins and could be the result of transcription factors expressed in AML.
Subject: Acute Disease
Dna Mutational Analysis
Dna, Neoplasm
Enzyme Induction
Flow Cytometry
Gene Expression Regulation, Leukemic
Genes, P53
Genes, Ras
Immunoenzyme Techniques
Leukemia, Myeloid
Neoplasm Proteins
Nitric Oxide Synthase
Nitric Oxide Synthase Type Ii
Polymerase Chain Reaction
Polymorphism, Single-stranded Conformational
Transcription, Genetic
Tumor Suppressor Protein P53
Ras Proteins
Rights: fechado
Identifier DOI: 
Date Issue: 2001
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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