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Type: Artigo de periódico
Title: Effect Of Bjcul (a Lectin From The Venom Of The Snake Bothrops Jararacussu) On Adhesion And Growth Of Tumor And Endothelial Cells.
Author: de Carvalho, D D
Schmitmeier, S
Novello, J C
Markland, F S
Abstract: Lectins are polyvalent carbohydrate-binding proteins of non-immune origin. Recently, we have isolated and characterized a lectin from the venom of the snake Bothrops jararacussu. This lectin (BJcuL) has been shown to bind to lactose moieties and induce agglutination of erythrocytes. In the present work, we observed that cells from human metastatic breast cancer (MDA-MB-435) and human ovarian carcinoma (OVCAR-5) cell lines adhere, although weakly, to BJcuL. However, BJcuL did not inhibit adhesion of these cells to the extracellular matrix proteins fibronectin, laminin and type I collagen. Importantly, viability of these tumor cells and cells from other human tumor cell lines and a bovine brain endothelial cell line was suppressed by BJcuL. These findings suggest that the lectin BJcuL may serve as an interesting tool for combating tumor progression by inhibiting tumor cell and endothelial cell growth.
Subject: Animals
Blood Vessels
Breast Neoplasms
Cell Adhesion
Cell Division
Cell Survival
Crotalid Venoms
Dose-response Relationship, Drug
Endothelium, Vascular
Extracellular Matrix Proteins
Neoplasm Metastasis
Ovarian Neoplasms
Tumor Cells, Cultured
Urinary Bladder Neoplasms
Citation: Toxicon : Official Journal Of The International Society On Toxinology. v. 39, n. 10, p. 1471-6, 2001-Oct.
Rights: fechado
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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