Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194728
Type: Artigo de periódico
Title: Artificial Articular Cartilage: Mechanoelectrical Transduction Under Dynamic Compressive Loading.
Author: Malmonge, S M
Arruda, A C
Abstract: The search for biomaterials to be used as an artificial articular cartilage in joint restoration is a challenging research area. Because the articular cartilage plays a fundamental role in joint function, the biomaterial has to be able to mimic the behavior of the natural healthy surface. Articular cartilage is a biphasic material composed by a solid extracellular matrix and a fluid phase, the synovial fluid. When the tissue is pressed, there is a mechanoelectrical transduction that is believed to modulate the cellular activity of chondrocytes, being fundamental for tissue repair. This work aimed at the development of hydrogels for use as an artificial articular cartilage. Hydrogels with negative groups fixed in the macromolecular network were obtained by copolymerizing 2-hydroxyethyl methacrylate with acrylic acid. The obtained hydrogels showed a mechanoelectrical transduction under dynamic compressive loading with potential amplitude increasing with fixed charge density values.
Subject: Acrylates
Biocompatible Materials
Biomechanical Phenomena
Cartilage, Articular
Chemistry, Physical
Chondrocytes
Electrochemistry
Extracellular Matrix
Humans
Hydrogels
Methacrylates
Physicochemical Phenomena
Prostheses And Implants
Prosthesis Design
Stress, Mechanical
Synovial Fluid
Weight-bearing
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10759634
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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