Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194712
Type: Artigo de periódico
Title: Tissue-specific Regulation Of Irs-2/pi 3-kinase Association In Aged Rats.
Author: Carvalho, C R
Maeda, L
Brenelli, S L
Saad, M J
Abstract: We have examined the insulin-stimulated IRS-2 association with PI 3-kinase and the phosphorylation of AKT/PKB, which is functionally located downstream of the PI 3-kinase, in aged (obese) rats. The IRS-2 protein levels were similar in 2 and 20 month-old rats in both tissues, liver and muscle. There were reductions in insulin-induced IRS-2 tyrosine phosphorylation in liver and muscle, accompanied by a decrease in IRS-2/PI 3-kinase association and in AKT/PKB phosphorylation only in muscle tissue of aged rats. This regulation may be important in the altered glucose metabolism observed in aged (obese) rats.
Subject: Aging
Animals
Insulin
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides And Proteins
Phosphatidylinositol 3-kinases
Phosphoproteins
Phosphorylation
Protein Binding
Rats
Signal Transduction
Tyrosine
Rights: fechado
Identifier DOI: 10.1515/BC.2000.010
Address: http://www.ncbi.nlm.nih.gov/pubmed/10722053
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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