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|Type:||Artigo de periódico|
|Title:||Tissue-specific Regulation Of Irs-2/pi 3-kinase Association In Aged Rats.|
|Author:||Carvalho, C R|
Brenelli, S L
Saad, M J
|Abstract:||We have examined the insulin-stimulated IRS-2 association with PI 3-kinase and the phosphorylation of AKT/PKB, which is functionally located downstream of the PI 3-kinase, in aged (obese) rats. The IRS-2 protein levels were similar in 2 and 20 month-old rats in both tissues, liver and muscle. There were reductions in insulin-induced IRS-2 tyrosine phosphorylation in liver and muscle, accompanied by a decrease in IRS-2/PI 3-kinase association and in AKT/PKB phosphorylation only in muscle tissue of aged rats. This regulation may be important in the altered glucose metabolism observed in aged (obese) rats.|
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides And Proteins
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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