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|Type:||Artigo de periódico|
|Title:||Protective Immunity Induced By A Trypanosoma Cruzi Soluble Extract Antigen In Experimental Chagas' Disease. Role Of Interferon Gamma.|
|Author:||Garcia, C A|
Oliveira, E C
Sakurada, J K
Santos, L M
|Abstract:||CBA/J mice can be protected against lethal infection with Trypanosoma cruzi by treatment using T. cruzi soluble extract antigen (TCSE). In vivo administration of TCSE (400 microg/mouse) into naive mice increased the cellular proliferative response to Con A and elevated the levels of IFN-gamma. The production of IFN-gamma was extremely important in controlling the replication of the parasite since the protective activity of TCSE was completely abrogated by in vivo treatment with an anti IFN-gamma neutralizing antibody. These results suggest that depending on the level, cytokine production results in the control of replication of the parasite in experimental Chagas' disease.|
Dose-response Relationship, Immunologic
Mice, Inbred Cba
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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