Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194688
Type: Artigo de periódico
Title: Protective Immunity Induced By A Trypanosoma Cruzi Soluble Extract Antigen In Experimental Chagas' Disease. Role Of Interferon Gamma.
Author: Garcia, C A
Oliveira, E C
Sakurada, J K
Santos, L M
Abstract: CBA/J mice can be protected against lethal infection with Trypanosoma cruzi by treatment using T. cruzi soluble extract antigen (TCSE). In vivo administration of TCSE (400 microg/mouse) into naive mice increased the cellular proliferative response to Con A and elevated the levels of IFN-gamma. The production of IFN-gamma was extremely important in controlling the replication of the parasite since the protective activity of TCSE was completely abrogated by in vivo treatment with an anti IFN-gamma neutralizing antibody. These results suggest that depending on the level, cytokine production results in the control of replication of the parasite in experimental Chagas' disease.
Subject: Animals
Antibodies, Blocking
Antigens, Protozoan
Cell-free System
Chagas Disease
Concanavalin A
Dose-response Relationship, Immunologic
Female
Interferon-gamma
Lymphocyte Activation
Mice
Mice, Inbred Cba
Protozoan Vaccines
Solubility
Spleen
Trypanosoma Cruzi
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10709842
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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