Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194676
Type: Artigo de periódico
Title: Platelet-derived Growth Factor/insulin-like Growth Factor-1 Combination And Bone Regeneration Around Implants Placed Into Extraction Sockets: A Histometric Study In Dogs.
Author: Stefani, C M
Machado, M A
Sallum, E A
Sallum, A W
Toledo, S
Nociti, F H
Abstract: This study evaluated, by histometric analysis, the wound healing process of bone around implants placed into extraction sockets with or without the concurrent application of a combination of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF-1). Mandibular premolars were removed, and 32 implants were inserted in eight dogs. Before insertion, two implants received a single application of 5 micrograms/mL of PDGF and IGF-1 delivered in 0.10 mL of 4% methylcellulose gel or 0.10 mL of 4% methylcellulose gel only as a control. To label regenerated bone, a 2% calcein green solution was administered by intramuscular injection at 0, 7, 15, 30, 45, 60, and 75 days after implant insertion. Three, 8, and 12 weeks after implant insertion, undecalcified sections were obtained, and the degree of bone contact with the implant surface, the bone area, and the intensity of bone labeling were measured into the limits of the threads of the implant. Greater extension of bone/implant contact (paired t test, P < .05) was observed in test (22.4% +/- 13.7%) than in control (17.2% +/- 13.6%) implants at 3 weeks. One-way ANOVA revealed a higher intensity of bone labeling (P < .05) at 3 weeks than at 12 weeks (127.8 +/- 42.59 and 56.7 +/- 26.34, gray scale values) for test implants. Within the limits of the present study, it was concluded that the combination of PDGF/IGF-I actively took part in the initial phase of bone repair.
Subject: Analysis Of Variance
Animals
Bicuspid
Bone Regeneration
Dental Implantation, Endosseous
Dental Implants
Dogs
Drug Combinations
Fluoresceins
Fluorescent Dyes
Follow-up Studies
Gels
Insulin-like Growth Factor I
Mandible
Methylcellulose
Osseointegration
Platelet-derived Growth Factor
Random Allocation
Statistics As Topic
Surface Properties
Tooth Extraction
Tooth Socket
Wound Healing
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11314699
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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