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Type: Artigo de periódico
Title: Anti-leishmanial Activity Of Neolignans From Virola Species And Synthetic Analogues.
Author: Barata, L E
Santos, L S
Ferri, P H
Phillipson, J D
Paine, A
Croft, S L
Abstract: Surinamensin, a neolignan isolated from Virola surinamensis, 3,4,5-trimethoxy-8-[2',6'-dimethoxy-4'-(E)-propenylphenoxy]-phenylpropane, a neolignan isolated from Virola pavonis, and 25 of its synthetic analogues or correlated substances with ether linkages and their corresponding C-8 sulphur and nitrogen analogues, were tested for activity against Leishmania donovani amastigotes and promastigotes in vitro. Some were active against L. donovani promastigotes at 30 microM but inactive against intracellular amastigotes. The natural neolignan from V. pavonis was active against promastigotes at 100 microM. The highest selective activity was found in those compounds with sulphur bridges. The beta-ketosulfide (3,4-dimethoxy)-8-(4'-methylthiophenoxy)-propiophenone produced 42% inhibition of L. donovani amastigotes in the liver of BALB/c mice at 100 mg/kg given once daily for five consecutive days (P>0.05).
Subject: Angiosperms
Antiprotozoal Agents
Disease Models, Animal
Drug Evaluation, Preclinical
Leishmania Donovani
Leishmaniasis, Visceral
Mice, Inbred Balb C
Rights: fechado
Identifier DOI: 
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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