Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194632
Type: Artigo de periódico
Title: Congenital Destructive Hemispheric Lesions And Epilepsy: Clinical Features And Relevance Of Associated Hippocampal Atrophy.
Author: Teixeira, R A
Leone, A A
Honorato, D C
Damasceno, B P
Guerreiro, C A
Cendes, F
Abstract: We studied the clinical, EEG and MRI findings in 19 patients with epilepsy secondary to congenital destructive hemispheric insults. Patients were divided in two groups: 10 with cystic lesions (group 1), and 9 with atrophic lesions (group 2). Seizure and EEG features, as well as developmental sequelae were similar between the two groups, except for the finding that patients of group 2 more commonly presented seizures with more than one semiological type. MRI showed hyperintense T2 signal extending beyond the lesion in almost all patients of both groups, and it was more diffuse in group 2. Associated hippocampal atrophy (HA) was observed in 70% of group 1 patients and 77.7% of group 2, and it was not correlated with duration of epilepsy or seizure frequency. There was a good concordance between HA and electroclinical localization. The high prevalence of associated HA in both groups suggests a common pathogenesis with the more obvious lesion. Our findings indicate that in some of these patients with extensive destructive lesions, there may be a more circumscribed epileptogenic area, particularly in those with cystic lesions and HA, leading to a potential rationale for effective surgical treatment.
Subject: Adolescent
Adult
Atrophy
Central Nervous System Cysts
Chi-square Distribution
Child
Child, Preschool
Electroencephalography
Epilepsy
Female
Hippocampus
Humans
Infant
Magnetic Resonance Imaging
Male
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/11105063
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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