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Type: Artigo de periódico
Title: Preliminary X-ray Diffraction Studies Of Rabbit Muscle Triose Phosphate Isomerase (tim).
Author: Aparicio, R
Ferreira, S T
Leite, N R
Polikarpov, I
Abstract: Triose phosphate isomerase (TIM) is responsible for the interconversion between GAP and DHAP in the glycolytic pathway. Two crystal forms belonging to space group P2(1)2(1)2(1) were obtained by the hanging-drop method and were designated A and B. Synchrotron X-ray diffraction data were collected for both forms. Form A had unit-cell parameters a = 65.14, b = 72.45, c = 93.24 A and diffracted to 2.25 A at 85 K, whereas form B had unit-cell parameters a = 73.02, b = 79.80, c = 172.85 A and diffracted to 2.85 A at room temperature. Molecular replacement was employed to solve the structures, using human TIM as a search model. Further refinement of both structures is under way and is expected to shed light on the recently reported conformational studies for rabbit TIM.
Subject: Animals
Crystallography, X-ray
Protein Conformation
Triose-phosphate Isomerase
Citation: Acta Crystallographica. Section D, Biological Crystallography. v. 56, n. Pt 11, p. 1492-4, 2000-Nov.
Rights: aberto
Identifier DOI: 
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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