Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194563
Type: Artigo de periódico
Title: Cytokine Profile And Natural Killer Cell Activity In Listeria Monocytogenes Infected Mice Treated Orally With Petiveria Alliacea Extract.
Author: Queiroz, M L
Quadros, M R
Santos, L M
Abstract: In this work, we investigated the effects of Petiveria alliacea extract on the production of Th1-type and Th2-type cytokines and on NK cells activity in normal and Listeria monocytogenes infected mice. Our results demonstrated that in normal/non-infected mice P. alliacea administration led to increased levels of Interleukin-2 (IL-2). The infection alone enhanced INF-gamma levels and NK cell activity at 48 and 72 hours of infection. The treatment with five consecutive doses of 1000 mg/kg/day of P. alliacea extract, given previously to infection, led to further increases in IL-2 levels, in relation to normal/non-infected/P. alliacea treated controls, and in INF-gamma levels at 72 h of infection, compared to infected mice. On the other hand, the production of IL-4 and IL-10 were not altered either by the infection or by the treatment with P. alliacea extract. NK cells activity increased at 48 h and 72 h following the inoculation of the bacteria. When mice were treated with P. alliacea previously to infection, NK activity was higher than that observed at 48 h, 72 h and 120 h of infection in the infected animal. Based on these findings we suggest that P. alliacea up-regulates anti-bacterial immune response by enhancing both Th1 function and the activity of NK cells.
Subject: Administration, Oral
Angiosperms
Animals
Cytokines
In Vitro Techniques
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-4
Killer Cells, Natural
Listeriosis
Male
Mice
Mice, Inbred Balb C
Plant Extracts
Plants, Medicinal
Th1 Cells
Th2 Cells
Rights: fechado
Identifier DOI: 10.3109/08923970009026008
Address: http://www.ncbi.nlm.nih.gov/pubmed/10946828
Date Issue: 2000
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File SizeFormat 
pmed_10946828.pdf380.14 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.