Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194531
Type: Artigo de periódico
Title: Bacterial Chemistry. Vi. Biological Activities And Cytotoxicity Of 1,3-dihydro-2h-indol-2-one Derivatives.
Author: Haun, M
Pereira, M F
Hoffmann, M E
Joyas, A
Campos, V
Filardi, L D
de Castro, S L
Duran, N
Abstract: The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.
Subject: Animals
Anti-bacterial Agents
Bacteria
Cell Line
Cell Survival
Chromobacterium
Cricetinae
Fibroblasts
Hemolysis
Indoles
Microbial Sensitivity Tests
Nifurtimox
Pigments, Biological
Trypanosoma Cruzi
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/1341576
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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