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Type: Artigo de periódico
Title: Bacterial Chemistry. Vi. Biological Activities And Cytotoxicity Of 1,3-dihydro-2h-indol-2-one Derivatives.
Author: Haun, M
Pereira, M F
Hoffmann, M E
Joyas, A
Campos, V
Filardi, L D
de Castro, S L
Duran, N
Abstract: The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.
Subject: Animals
Anti-bacterial Agents
Cell Line
Cell Survival
Microbial Sensitivity Tests
Pigments, Biological
Trypanosoma Cruzi
Citation: Biological Research. v. 25, n. 1, p. 21-5, 1992.
Rights: aberto
Identifier DOI: 
Date Issue: 1992
Appears in Collections:Unicamp - Artigos e Outros Documentos

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