Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194478
Type: Artigo de periódico
Title: Study Of The Vaginal Tolerance To Acidform, An Acid-buffering, Bioadhesive Gel.
Author: Amaral, E
Faúndes, A
Zaneveld, L
Waller, D
Garg, S
Abstract: Vaginal tolerance tests were performed with a new potential microbicidal and spermicidal product, an acid-buffering vaginal gel (Acidform) without or with nonoxynol-9 (N-9). The potential advantages over other vaginal products include keeping a low pH, decrease of the irritating effect of N-9 on the cervix or vaginal mucosa associated with greater retention of the product after application, and decreasing messiness as compared to other vaginal products. Three groups of six women were admitted and randomly assigned to use Acidform with 0%, 2.5%, and 5% N-9. Colposcopic evaluation for vulvar, vaginal, and cervical signs of irritation was performed and photographs were taken, following a specific World Health Organization protocol, at time 0, and after 24 h and 6 days of application of the gel. No irritation or symptom was reported by users of Acidform without N-9. A generalized and intense erythema in cervix was observed in 10 of 12 Acidform/N-9 users and abrasion occurred in nine of them. Vulvar irritation was seen in seven of these 10 volunteers. N-9 concentration in the gel (2.5% or 5.0%) was not related to the findings. No ulcer, exulceration, or de-epithelialization was observed. Acidform without N-9 was well tolerated by volunteers, but it was unable to protect the cervix, vagina, and vulva from the N-9 effects.
Subject: Adult
Cervix Uteri
Colposcopy
Double-blind Method
Erythema
Female
Gels
Humans
Hydrogen-ion Concentration
Leukocyte Count
Middle Aged
Nonoxynol
Sexually Transmitted Diseases
Spermatocidal Agents
Vagina
Vaginal Creams, Foams, And Jellies
Vulva
Americas
Biology
Brazil
Cervical Effects
Cervix
Clinical Research
Contraception
Contraceptive Agents
Contraceptive Methods
Developing Countries
Diseases
Family Planning
Genitalia
Genitalia, Female
Infections
Latin America
Nonoxynol-9
Physiology
Reproductive Tract Infections
Research Methodology
Research Report
Sexually Transmitted Diseases--prevention And Control
South America
Spermicidal Contraceptive Agents
Urogenital System
Uterus
Vaginal Jelly
Vaginal Spermicides
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10715372
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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