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Type: Artigo de periódico
Title: Evaluation Of In Vitro Toxicity Of N,n-dimethyl-2-propen-1-amines Isomers.
Author: Oliveira, D A
Fernandes, A M
De Conti, R
Rodríguez, J A
Haun, M
Souza-Brito, A R
De Castro, S L
Durán, N
Abstract: The trypanocidal activities of cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)- 3-(phenyl)-N,N-dimethyl-2-propen-1-amine (Vb) and cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-bromophenyl)-N,N-dimethyl-2- propen-1-anine (Vg) appeared 6.3 and 3.5 fold more active than the trans-isomers, respectively. Multi-endpoints for toxicity were also applied. Neutral red uptake (NRU), tetrazolium salt reduction (MTT), DNA content on V79 fibroblast cell culture and acute toxicity von E. coli were measured. The IC50 through DNA contents was lower for the cis-isomers in both series of compounds 5b: 7.8 microM and 5g: 5.2 microM). NRU values for derivative 5b in isomeric mixture shows the same value as the isolated isomers however, in the case of 5g a more significant toxicity of the cis-isomer was found. MTT values show that 5g is more toxic than 5b. In both cases, the acute toxicity of the trans-isomers was higher than that of the cis-isomers.
Subject: Amines
Cell Line
Cell Survival
Escherichia Coli
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Neutral Red
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Trypanocidal Agents
Tumor Cells, Cultured
Rights: fechado
Identifier DOI: 
Date Issue: 1999
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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