Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194456
Type: Artigo de periódico
Title: Evaluation Of In Vitro Toxicity Of N,n-dimethyl-2-propen-1-amines Isomers.
Author: Oliveira, D A
Fernandes, A M
De Conti, R
Rodríguez, J A
Haun, M
Souza-Brito, A R
De Castro, S L
Durán, N
Abstract: The trypanocidal activities of cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)- 3-(phenyl)-N,N-dimethyl-2-propen-1-amine (Vb) and cis-3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-bromophenyl)-N,N-dimethyl-2- propen-1-anine (Vg) appeared 6.3 and 3.5 fold more active than the trans-isomers, respectively. Multi-endpoints for toxicity were also applied. Neutral red uptake (NRU), tetrazolium salt reduction (MTT), DNA content on V79 fibroblast cell culture and acute toxicity von E. coli were measured. The IC50 through DNA contents was lower for the cis-isomers in both series of compounds 5b: 7.8 microM and 5g: 5.2 microM). NRU values for derivative 5b in isomeric mixture shows the same value as the isolated isomers however, in the case of 5g a more significant toxicity of the cis-isomer was found. MTT values show that 5g is more toxic than 5b. In both cases, the acute toxicity of the trans-isomers was higher than that of the cis-isomers.
Subject: Amines
Animals
Cell Line
Cell Survival
Cricetinae
Escherichia Coli
Isomerism
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Neutral Red
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Trypanocidal Agents
Tumor Cells, Cultured
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10603610
Date Issue: 1999
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.