Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194386
Type: Artigo de periódico
Title: Microsomal Metabolism Of Quinifuryl--a Nitrofuryl-ethenyl-quinolone Antiseptic Possessing Antitumor Activity In Vitro.
Author: Degterev, I A
Nogueira, P C
Marsaioli, A J
Verces, A E
Abstract: Quinifuryl, 2-(5'-nitro-2'-furanyl)ethenyl-4-[N-[4'-(N,N-diethylamino)-1'-methylbuty l] carbamoyl] quinoline, is a representative of a family of nitrofuran-ethenyl-quinoline antibiotics synthesized in the USSR by Dr N.M. Sukhova. The drug has been shown to be an effective cytostatic and radiosensitizer towards cancer cells in culture. While rapid metabolic consumption of these drugs by liver tissue has been shown, none of the drug metabolites have been isolated and characterized. Here, we present the results of experiments focusing on the isolation and characterization of quinifuryl metabolites. A pyridine derivative was the sole product detected and characterized by GC-MS analysis. An alteration of quinifuryl metabolism by peroxynitrite formed during the metabolism of the drug was assumed to be responsible for an unexpectedly high drug decomposition.
Subject: Animals
Anti-infective Agents, Local
Antineoplastic Agents
Drug Interactions
Drug Stability
Gas Chromatography-mass Spectrometry
In Vitro Techniques
Male
Mice
Microsomes, Liver
Nitrates
Oxidants
Pyridines
Quinolines
Citation: European Journal Of Drug Metabolism And Pharmacokinetics. v. 24, n. 1, p. 15-22
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10412887
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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