Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194377
Type: Artigo de periódico
Title: Effects Of Bothrops Pirajai Venom On The Mouse Extensor Digitorum Longus (edl) Muscle Preparation.
Author: Costa, P D
Toyama, M H
Marangoni, S
Rodrigues-Simioni, L
da Cruz-Höfling, M A
Abstract: The effects of Bothrops pirajai snake venom on the mouse extensor digitorum longus (EDL) preparation were examined using myographic, histopathological and biochemical approaches. B. pirajai venom (10, 25 or 50 microg/ml) dose dependently and irreversibly blocked the contractile response of indirectly stimulated EDL muscle. Histopathological analysis of EDL muscle incubated with venom showed dose-dependent damage with a loss of the normal tissue structure and the appearance of highly dark, edematous fibers together with myofibrils in various stages of condensation. At high doses of venom (50 microg/ml), loss of muscle cells was observed. In non-stimulated EDL, B. pirajai venom (10 and 50 microg/ml) caused a time-dependent release of CK which was maximal after 120 min. These results suggest that a component(s) present in the B. pirajai venom has a direct myolytic action on the skeletal muscle.
Subject: Animals
Bothrops
Creatine Kinase
Dose-response Relationship, Drug
Electric Stimulation
In Vitro Techniques
Mice
Muscle Contraction
Muscle, Skeletal
Myography
Snake Venoms
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/10400298
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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