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|Type:||Artigo de periódico|
|Title:||Effect Of Toxin-g From Tityus Serrulatus Scorpion Venom On Gastric Emptying In Rats.|
Vinagre, A M
Collares, E F
|Abstract:||The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by injecting 50 micrograms of toxin-gamma/kg and measuring the effect on gastric emptying at times 0.25, 0.5, 1, 2, 4, 8, 24 and 48 h post-venom. Each envenomed animal was paired with its saline control and all received a saline test meal solution containing phenol red (60 micrograms/ml) as a marker. Ten minutes after administering the test meal by gavage the animals were sacrificed and gastric retention was determined by measuring the residual marker concentration of the test meal. A significant delay in gastric emptying, at 30 min and 8 h post-venom, was observed only after 50 and 100 micrograms of toxin-gamma/kg compared to control values. The responses to these two doses were significantly different after 8 h post-venom. Toxin-gamma (50 micrograms/kg) significantly delayed the gastric emptying of liquids at all times studied, with a peak response at 4 h after toxin administration compared to control values. These results indicate that the i.v. injection of toxin-gamma may induce a rapid, intense and sustained inhibition of gastric emptying 0.25 to 48 h after envenomation.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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