Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194328
Type: Artigo de periódico
Title: Mitochondrial Damage Induced By Conditions Of Oxidative Stress.
Author: Kowaltowski, A J
Vercesi, A E
Abstract: Up to 2% of the oxygen consumed by the mitochondrial respiratory chain undergoes one electron reduction, typically by the semiquinone form of coenzyme Q, to generate the superoxide radical, and subsequently other reactive oxygen species such as hydrogen peroxide and the hydroxyl radical. Under conditions in which mitochondrial generation of reactive oxygen species is increased (such as in the presence of Ca2+ ions or when the mitochondrial antioxidant defense mechanisms are compromised), these reactive oxygen species may lead to irreversible damage of mitochondrial DNA, membrane lipids and proteins, resulting in mitochondrial dysfunction and ultimately cell death. The nature of this damage and the cellular conditions in which it occurs are discussed in this review article.
Subject: Animals
Apoptosis
Dna Damage
Dna, Mitochondrial
Electron Transport
Humans
Lipid Peroxidation
Membrane Proteins
Mitochondria
Necrosis
Oxidation-reduction
Oxidative Stress
Permeability
Reactive Oxygen Species
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/9895239
Date Issue: 1999
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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