Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194312
Type: Artigo de periódico
Title: The Mechanisms And Significance Of The Coupled Release Of Endothelium-derived Relaxing Factor (edrf) And Prostacyclin (pgi2) From Endothelial Cells.
Author: Hyslop, S
de Nucci, G
Abstract: Endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) are co-released from endothelial cells by stimuli acting via membrane-bound receptors or via non-receptor mediated mechanisms. The receptor-mediated release of EDRF and PGI2 is calcium-dependent and seems to be under the negative feedback regulation of protein kinase C. Significant interactions between EDRF and PGI2 or between their respective second messengers within the endothelial cell have not yet been conclusively demonstrated. Furthermore, although EDRF and PGI2 synergize in the inhibition of platelet aggregation, there is little evidence for such synergism in smooth muscle relaxation. These observations indicate that EDRF and PGI2 release may be coupled primarily by their requirement for raised intracellular calcium levels and by their regulation through protein kinase C.
Subject: Animals
Calcium
Endothelium, Vascular
Epoprostenol
Humans
Muscle, Smooth, Vascular
Nitric Oxide
Platelet Aggregation
Thrombosis
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/1926869
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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