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Type: Artigo de periódico
Title: Acid Suppression With Ranitidine Plus Oral Triple Therapy Improves Ulcer Healing But Not Helicobacter Pylori Eradication.
Author: Magalhaes, A F
Macedo, C
Hauck, J R
Carvalhaes, A
De Nucci, G
Magna, L A
Pedrazzoli, J
Abstract: To evaluate whether the addition of 2 weeks of ranitidine to a 1-week oral triple therapy (OTT) regimen improved ulcer healing and H. pylori eradication. Two hundred and eleven consecutive patients with an endoscopic diagnosis of active duodenal ulcer (DU) and a positive antrum biopsy for H. pylori were enrolled. Those attending the Hospital Vera Cruz (Group A, n=142) received a 14-day course of ranitidine (150 mg after breakfast and dinner) plus a 1-week OTT, consisting of bismuth subcitrate, (240 mg after the 3 meals), tetracycline (500 mg, 10 min before the three meals and at bedtime), and furazolidone (200 mg after breakfast and dinner). Patients from the Hospital das Clinicas (Group B, n=69) received the same OTT as Group A but without ranitidine. Patients underwent endoscopy again on average 40 days (range: 30-60 days) after completing therapy in order to assess ulcer healing and H. pylori status. Both schedules were equally efficient in eradicating H. pylori with 90% (128/142) eradication in group A, and 84% (58/69) in group B (p=0.2). In contrast, the addition of ranitidine to OTT improved ulcer healing when compared with OTT alone (96%, 137/142, vs. 70%, 48/69; p<0.001). Our results demonstrate that the association of acid suppression, obtained with 2 week ranitidine administration with OTT improved ulcer healing but did not enhance H. pylori eradication.
Subject: Adolescent
Anti-ulcer Agents
Drug Administration Schedule
Drug Therapy, Combination
Duodenal Ulcer
Endoscopy, Gastrointestinal
Follow-up Studies
Gastric Acidity Determination
Helicobacter Infections
Helicobacter Pylori
Middle Aged
Organometallic Compounds
Prospective Studies
Pyloric Antrum
Treatment Outcome
Citation: Hepato-gastroenterology. v. 45, n. 24, p. 2161-4
Rights: aberto
Appears in Collections:Unicamp - Artigos e Outros Documentos

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