Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194285
Type: Artigo de periódico
Title: Differential Proliferation Of Fibroblasts Cultured From Hereditary Gingival Fibromatosis And Normal Gingiva.
Author: Coletta, R D
Almeida, O P
Graner, E
Page, R C
Bozzo, L
Abstract: Hereditary gingival fibromatosis (HGF) is an oral condition characterized by the enlargement of the gingiva of both the maxilla and mandible. To study the cell proliferation index of fibroblasts from HGF and normal gingiva (NG), cell cultures from 4 members of the same family with HGF and from 4 healthy patients were established. Our results obtained from 6 different cell proliferation assays clearly showed that the cell proliferation rate was significantly higher in fibroblasts from HGF than from normal gingiva. HGF and control fibroblasts in subconfluent culture densities were typically spindle, but in saturation density HGF cells were shorter than control cells. These data suggest that the higher proliferative index of HGF fibroblasts possibly has a role in the pathogenesis of gingival outgrowth in HGF patients.
Subject: Adult
Bromodeoxyuridine
Case-control Studies
Cell Division
Cells, Cultured
Colorimetry
Dna
Female
Fibroblasts
Fibromatosis, Gingival
Humans
Male
Nucleolus Organizer Region
Proliferating Cell Nuclear Antigen
Silver Staining
Tetrazolium Salts
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/9879520
Date Issue: 1998
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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