Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194255
Type: Artigo de periódico
Title: Angiotensin-converting Enzyme Inhibitor Increases Insulin-induced Pp185 Phosphorylation In Liver And Muscle Of Obese Rats.
Author: Carvalho, D S
Villaça, V
Brenelli, S L
Carvalho, C R
Saad, M J
Abstract: The clinical use of angiotensin-converting enzyme (ACE) inhibitors has been associated with increased insulin sensitivity. However, the molecular mechanism is unknown. The authors examined the early steps in insulin action, i.e., the phosphorylation status of the insulin receptor and of the pp185 in liver and muscle of obese rats treated acutely with captopril, using immunoblotting with antiphosphotyrosine antibodies. Following treatment with captopril there was an improvement in insulin-induced insulin receptor and pp185 phosphorylation in the liver and muscle of obese rats. This finding contribute to an explanation of the mechanism by which ACE inhibitors appear to improve insulin sensitivity.
Subject: Angiotensin-converting Enzyme Inhibitors
Animals
Captopril
Insulin
Insulin Receptor Substrate Proteins
Intracellular Signaling Peptides And Proteins
Liver
Male
Muscle, Skeletal
Obesity
Phosphoproteins
Phosphorylation
Phosphotyrosine
Rats
Rats, Wistar
Receptor, Insulin
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/9801794
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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