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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEthanol Reduces The Endothelin-b Receptor-mediated Increase In Portal Inflow Resistance In The Isolated, Perfused Canine Liver.pt_BR
dc.contributor.authorFaro, Fpt_BR
dc.contributor.authorFerraz, J Gpt_BR
dc.contributor.authorStella, H Jpt_BR
dc.contributor.authorFaro, Rpt_BR
dc.contributor.authorAntunes, Ept_BR
dc.contributor.authorOpgennorth, T Jpt_BR
dc.contributor.authorWithrington, P Gpt_BR
dc.contributor.authorde Nucci, Gpt_BR
unicamp.authorF Faro, Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), SP, Brazil.pt_BR
unicamp.author.externalJ G Ferraz,pt
unicamp.author.externalH J Stella,pt
unicamp.author.externalR Faro,pt
unicamp.author.externalE Antunes,pt
unicamp.author.externalT J Opgennorth,pt
unicamp.author.externalP G Withrington,pt
unicamp.author.externalG de Nucci,pt
dc.subjectAdrenergic Alpha-agonistspt_BR
dc.subjectAnimalspt_BR
dc.subjectCentral Nervous System Depressantspt_BR
dc.subjectDogspt_BR
dc.subjectEndothelin Receptor Antagonistspt_BR
dc.subjectEndothelin-1pt_BR
dc.subjectEndothelinspt_BR
dc.subjectEthanolpt_BR
dc.subjectLiver Circulationpt_BR
dc.subjectNorepinephrinept_BR
dc.subjectPeptide Fragmentspt_BR
dc.subjectPortal Pressurept_BR
dc.subjectReceptor, Endothelin Apt_BR
dc.subjectReceptor, Endothelin Bpt_BR
dc.subjectReceptors, Endothelinpt_BR
dc.subjectVascular Resistancept_BR
dc.description.abstractEthanol can affect the regulation of liver hemodynamics through the release of vasoactive mediators such as nitric oxide and endothelins (ETs). The purpose of this study was to investigate the effects of ethanol on the changes in arterial and portal perfusion pressure induced by ET receptor activation. Ethanol significantly reduced portal, but not arterial perfusion pressure. ET-1 and norepinephrine (used as an ET receptor-independent vasoconstrictor) induced changes in hepatic arterial or portal inflow resistance that were not affected by ethanol treatment. However, an IRL 1620-induced increase in portal, but not arterial, inflow resistance was significantly reduced in ethanol-perfused preparations, an effect observed after either intra-arterial or intraportal administration of the agonist. These results suggest that ethanol can diminish the responsiveness of the portal vascular bed of the canine liver to ETB receptor activation.en
dc.relation.ispartofJournal Of Cardiovascular Pharmacologypt_BR
dc.relation.ispartofabbreviationJ. Cardiovasc. Pharmacol.pt_BR
dc.date.issued1998pt_BR
dc.identifier.citationJournal Of Cardiovascular Pharmacology. v. 31 Suppl 1, p. S284-6, 1998.pt_BR
dc.language.isoengpt_BR
dc.description.volume31 Suppl 1pt_BR
dc.description.firstpageS284-6pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0160-2446pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/9595460pt_BR
dc.date.available2015-11-27T12:19:13Z-
dc.date.accessioned2015-11-27T12:19:13Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:19:13Z (GMT). No. of bitstreams: 0 Previous issue date: 1998. Added 1 bitstream(s) on 2019-03-14T14:32:24Z : No. of bitstreams: 1 9595460.pdf: 943984 bytes, checksum: 5d25ba977defe1c387f1b8292cbb2d3a (MD5) Bitstreams deleted on 2020-05-18T20:40:59Z: 9595460.pdf,. Added 1 bitstream(s) on 2020-05-19T14:30:46Z : No. of bitstreams: 1 9595460.pdf: 704279 bytes, checksum: d11a2a1290b52e22ced6976fd2ef1794 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194167-
dc.identifier.idPubmed9595460pt_BR
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