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Type: Artigo de periódico
Title: Immunodepression Induced By Trypanosoma Cruzi And Mouse Hepatitis Virus Type 3 Is Associated With Thymus Apoptosis.
Author: Verinaud, L
Da Cruz-Höfling, M A
Sakurada, J K
Rangel, H A
Vassallo, J
Wakelin, D
Sewell, H F
Camargo, I J
Abstract: Trypanosoma cruzi-infected mice show disturbance in the peripheral immune system such as polyclonal lymphocyte activation, autoantibody production, and immunosuppression of T lymphocytes. Previous observations in our laboratory showed that some stocks of T. cruzi can be contaminated with mouse hepatitis virus type 3 (MHV-3). Literature has shown that MHV-3 infection induces immunologic disorders characterized by thymic involution with marked cell depletion. However, the effects of interactions between MHV-3 and the parasite on the immune system are not well understood. In the present study specific-pathogen-free CBA mice were inoculated with MHV-3, alone or associated with different stocks of T. cruzi. Concurrent murine virus infection resulted in increased pathogenicity of T. cruzi infection shown by profound thymic atrophy; loss of cortical thymocytes; depletion of Thy1.2+, CD4+, and CD8+ cells; enhancement of in situ labeling of nuclear DNA fragmentation; and eventually, death of the animals. Such lines of evidence show that the mechanism underlying this thymic atrophy is associated with apoptosis. These results also suggest that MHV-3 can account for the increased immunosuppression observed during experimental infection with the parasite.
Subject: Animals
Chagas Disease
Hepatitis, Viral, Animal
Mice, Inbred Cba
Murine Hepatitis Virus
Thymus Gland
Trypanosoma Cruzi
Rights: aberto
Identifier DOI: 
Date Issue: 1998
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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