Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194110
Type: Artigo de periódico
Title: Viscosity Of Gums In Vitro And Their Ability To Reduce Postprandial Hyperglycemia In Normal Subjects.
Author: Brenelli, S L
Campos, S D
Saad, M J
Abstract: Experiments were carried out in vitro with three viscous polysaccharides (guar gum, pectin, and carboxymethylcellulose (CMC) of similar initial viscosity submitted to conditions that mimic events occurring in the stomach and duodenum, and their viscosity in these situations was compared to their actions on postprandial hyperglycemia in normal human subjects. Guar gum showed greater viscosity than the other gums during acidification and/or alkalinization and also showed larger effects on plasma glucose levels (35% reduction in maximum rise in plasma glucose) and on the total area under the curve of plasma glucose (control: 20,314 +/- 1007 mg dl-1 180 min-1 vs guar gum: 18,277 +/- 699 mg dl-1 180 min-1, P < 0.01). Pectin, which showed a marked reduction in viscosity at 37 degrees C and after events mimicking those that occur in the stomach and duodenum, did not have a significant effect on postprandial hyperglycemia. The performance of viscosity and the glycemia response to CMC were at an intermediate level between guar gum and pectin. In conclusion, these data suggest that temperature, the process of acidification, alkalinization and exposure to intestinal ions induce different viscosity changes in gums having similar initial viscosity, establishing a direct relationship between a minor decrease of gum viscosity in vitro and a reduction of postprandial hyperglycemia.
Subject: Adult
Antidiarrheals
Carboxymethylcellulose Sodium
Cathartics
Female
Galactans
Humans
Hyperglycemia
Male
Mannans
Pectins
Plant Gums
Polysaccharides
Postprandial Period
Viscosity
Rights: aberto
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/9686163
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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