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Type: Artigo de periódico
Title: Ciliary Neurotrophic Factor Stimulates In Vivo Myotube Formation In Mice.
Author: Marques, M J
Neto, H S
Abstract: It is known that ciliary neurotrophic factor (CNTF) administration reduces the atrophy observed with denervation, suggesting its role as a trophic factor for muscle cells. At the present, we studied the effects of 'in vivo' CNTF administration on the regenerative capacity of skeletal muscle fibres. Adult mice had their extensor digitorium longus muscle subjected to a denervation-devascularization lesion. CNTF (0.5 ng/microl) was administered using osmotic pumps implanted subcutaneously in unrestrained mice. CNTF was delivered into the muscle's region at a rate of 1 microl/h from 1 to 8 days after denervation. The results show that CNTF increased the number of regenerating myofibres by day 4. From day 7 on, the values seen on control and CNTF-treated groups were not significantly different. Our results show that 'in vivo' CNTF administration accelerates myotube differentiation.
Subject: Animals
Cell Differentiation
Ciliary Neurotrophic Factor
Embryonic And Fetal Development
Infusion Pumps, Implantable
Muscle, Skeletal
Nerve Growth Factors
Nerve Tissue Proteins
Stimulation, Chemical
Rights: fechado
Identifier DOI: 
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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