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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffect Of Bacterial Lipopolysaccharide On Gastric Emptying Of Liquids In Rats.pt_BR
dc.contributor.authorCollares, E Fpt_BR
unicamp.authorE F Collares, Departamento de Pediatria and Núcleo de Medicina e Cirurgia Experimental, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brasil.pt_BR
dc.subjectAnimalspt_BR
dc.subjectBacterial Infectionspt_BR
dc.subjectEscherichia Colipt_BR
dc.subjectGastric Emptyingpt_BR
dc.subjectLipopolysaccharidespt_BR
dc.subjectMalept_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectVagotomypt_BR
dc.description.abstractThe objectives of the present investigation were 1) to study the effect of bacterial lipopolysaccharide (LPS) on rat gastric emptying (GE) and 2) to investigate a possible involvement of the vagus nerve in the gastric action of LPS. Endotoxin from E. coli (strain 055:B5) was administered sc, ip or iv to male Wistar rats (220-280 g body weight) at a maximum dose of 50 micrograms/kg animal weight. Control animals received an equivalent volume of sterile saline solution. At a given time period after LPS administration, GE was evaluated by measuring gastric retention 10 min after the orogastric infusion of a test meal (2 ml/100 g animal weight), which consisted of 0.9% NaCl plus the marker phenol red (6 mg/dl). One group of animals was subjected to bilateral subdiaphragmatic vagotomy or sham operation 15 days before the test. A significant delay in GE of the test meal was observed 5 h after iv administration of the endotoxin at the dose of 50 micrograms/kg animal weight. The LPS-induced delay of GE was detected as early as 30 min and up to 8 h after endotoxin administration. The use of different doses of LPS ranging from 5 to 50 micrograms/kg animal weight showed that the alteration of GE was dose dependent. In addition, vagotomized animals receiving LPS displayed a GE that was not significantly different from that of the sham control group. However, a participation of the vagus nerve in LPS-induced delay in GE could not be clearly demonstrated by these experiments since vagotomy itself induced changes in this gastric parameter. The present study provides a suitable model for identifying the mechanisms underlying the effects of LPS on gastric emptying.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued1997-Febpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 30, n. 2, p. 207-11, 1997-Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume30pt_BR
dc.description.firstpage207-11pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/9239306pt_BR
dc.date.available2015-11-27T12:18:59Z-
dc.date.accessioned2015-11-27T12:18:59Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T12:18:59Z (GMT). No. of bitstreams: 1 pmed_9239306.pdf: 196306 bytes, checksum: a81d9780d3d10cb109ffdcb02d434a12 (MD5) Previous issue date: 1997en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194042-
dc.identifier.idPubmed9239306pt_BR
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