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Type: Artigo de periódico
Title: The Role Of Reactive Oxygen Species In Mitochondrial Permeability Transition.
Author: Vercesi, A E
Kowaltowski, A J
Grijalba, M T
Meinicke, A R
Castilho, R F
Abstract: We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca(2+)-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The ROS attack to membrane protein thiols produces cross-linkage reactions, that may open membrane pores upon Ca2+ binding. Studies with submitochondrial particles have demonstrated that the binding of Ca2+ to these particles (possibly to cardiolipin) induces lipid lateral phase separation detected by electron paramagnetic resonance experiments exploying stearic acids spin labels. This condition leads to a disorganization of respiratory chain components, favoring ROS production and consequent protein and lipid oxidation.
Subject: Animals
Intracellular Membranes
Models, Molecular
Oxidative Stress
Reactive Oxygen Species
Citation: Bioscience Reports. v. 17, n. 1, p. 43-52, 1997-Feb.
Rights: aberto
Identifier DOI: 
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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