Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194024
Type: Artigo de periódico
Title: N-ras Gene Point Mutations In Brazilian Acute Myelogenous Leukemia Patients Correlate With A Poor Prognosis.
Author: De Melo, M B
Lorand-Metze, I
Lima, C S
Saad, S T
Costa, F F
Abstract: The frequency of ras gene mutations varies from 11 to 27% in AML populations from the United States and Europe but it seems that there is no study regarding the frequency of mutated N-ras gene in patients with AML in South America. In order to study the frequency of N-ras gene mutations (exons 1 and 2) in Brazilian patients with AML and to evaluate the possible correlation between the presence of the mutation and clinical features, 40 patients were analyzed. N-ras mutations were identified in DNA samples from eight of 40 AML patients (20%). No significant correlation was found between N-ras mutation and age, sex, race, response to therapy, FAB subtype or occupational exposure. However, the overall survival and AML-free survival were significantly shorter in patients with N-ras mutations than in those without these abnormalities.
Subject: Acute Disease
Adult
Aged
Aged, 80 And Over
Brazil
Continental Population Groups
Dna, Neoplasm
Exons
Female
Gene Frequency
Genes, Ras
Humans
Leukemia, Myeloid
Life Tables
Male
Middle Aged
Point Mutation
Prognosis
Survival Analysis
Treatment Outcome
Rights: fechado
Identifier DOI: 10.3109/10428199709039018
Address: http://www.ncbi.nlm.nih.gov/pubmed/9156660
Date Issue: 1997
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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