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Type: Artigo de periódico
Title: N-ras Gene Point Mutations In Brazilian Acute Myelogenous Leukemia Patients Correlate With A Poor Prognosis.
Author: De Melo, M B
Lorand-Metze, I
Lima, C S
Saad, S T
Costa, F F
Abstract: The frequency of ras gene mutations varies from 11 to 27% in AML populations from the United States and Europe but it seems that there is no study regarding the frequency of mutated N-ras gene in patients with AML in South America. In order to study the frequency of N-ras gene mutations (exons 1 and 2) in Brazilian patients with AML and to evaluate the possible correlation between the presence of the mutation and clinical features, 40 patients were analyzed. N-ras mutations were identified in DNA samples from eight of 40 AML patients (20%). No significant correlation was found between N-ras mutation and age, sex, race, response to therapy, FAB subtype or occupational exposure. However, the overall survival and AML-free survival were significantly shorter in patients with N-ras mutations than in those without these abnormalities.
Subject: Acute Disease
Aged, 80 And Over
Continental Population Groups
Dna, Neoplasm
Gene Frequency
Genes, Ras
Leukemia, Myeloid
Life Tables
Middle Aged
Point Mutation
Survival Analysis
Treatment Outcome
Citation: Leukemia & Lymphoma. v. 24, n. 3-4, p. 309-17, 1997-Jan.
Rights: fechado
Identifier DOI: 10.3109/10428199709039018
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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