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Type: Artigo de periódico
Title: Acute Inhibition Of Nitric Oxide Synthesis Induces Anxiolysis In The Plus Maze Test.
Author: Faria, M S
Muscará, M N
Moreno Júnior, H
Teixeira, S A
Dias, H B
De Oliveira, B
Graeff, F G
De Nucci, G
Abstract: The involvement of nitric oxide (NO) in anxiety was investigated in rats, using the elevated plus maze test. Acute, but not chronic, systemic treatment with N omega-nitro-L-arginine methyl ester (L-NAME, 10 and 60, an inhibitor of NO synthase, increased the time spent by the rats in the open arms. Both the acute and chronic treatments with L-NAME inhibited NO synthase in endothelial cells and in the central nervous system, as shown by the increase in mean arterial pressure and decreased NO synthase activity in brain tissue. Chronic treatment with L-NAME also decreased the serum nitrate levels. The anxiolysis induced by acute L-NAME treatment is unlikely to be due to hypertension, since two-kidney one-clip hypertension in non-L-NAME-treated rats failed to significantly change exploratory behaviour in the elevated plus maze. These results indicate that acute inhibition of NO synthesis decreases anxiety in rats.
Subject: Analysis Of Variance
Anti-anxiety Agents
Blood Pressure
Central Nervous System
Enzyme Inhibitors
Hypertension, Renal
Maze Learning
Ng-nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Synthase
Rats, Wistar
Citation: European Journal Of Pharmacology. v. 323, n. 1, p. 37-43, 1997-Mar.
Rights: fechado
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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