Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/194017
Type: Artigo de periódico
Title: Acute Inhibition Of Nitric Oxide Synthesis Induces Anxiolysis In The Plus Maze Test.
Author: Faria, M S
Muscará, M N
Moreno Júnior, H
Teixeira, S A
Dias, H B
De Oliveira, B
Graeff, F G
De Nucci, G
Abstract: The involvement of nitric oxide (NO) in anxiety was investigated in rats, using the elevated plus maze test. Acute, but not chronic, systemic treatment with N omega-nitro-L-arginine methyl ester (L-NAME, 10 and 60 mg.kg-1), an inhibitor of NO synthase, increased the time spent by the rats in the open arms. Both the acute and chronic treatments with L-NAME inhibited NO synthase in endothelial cells and in the central nervous system, as shown by the increase in mean arterial pressure and decreased NO synthase activity in brain tissue. Chronic treatment with L-NAME also decreased the serum nitrate levels. The anxiolysis induced by acute L-NAME treatment is unlikely to be due to hypertension, since two-kidney one-clip hypertension in non-L-NAME-treated rats failed to significantly change exploratory behaviour in the elevated plus maze. These results indicate that acute inhibition of NO synthesis decreases anxiety in rats.
Subject: Analysis Of Variance
Animals
Anti-anxiety Agents
Anxiety
Arginine
Blood Pressure
Brain
Central Nervous System
Diazepam
Enzyme Inhibitors
Hypertension, Renal
Male
Maze Learning
Ng-nitroarginine Methyl Ester
Nitrates
Nitric Oxide
Nitric Oxide Synthase
Rats
Rats, Wistar
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/9105874
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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