Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193937
Type: Artigo de periódico
Title: Glutathione Peroxidase, Reduced Glutathione, Superoxide Dismutase And Catalase In Red Cells Of Patients With Hairy Cell Leukemia.
Author: Arruda, V R
Salles, T S
Costa, F F
Saad, S T
Abstract: Red cell antioxidant enzymes have been recently studied in malignant lymphomas and the results are controversial. Hairy cell leukemia is a rare chronic lymphoproliferative disorder originating probably in a pluripotent stem cell. In the present study, glutathione peroxidase (Gpx), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase were measured in a homogeneous group of patients with untreated hairy cell leukemia and normal controls. Glutathione peroxidase, catalase and SOD activities were significantly lower in patients than in normals. GSH was not significantly different in patients compared to controls. There was no correlation between Gpx, GSH, SOD, and catalase and hemoglobin; reticulocytes, leukocytes, hairy cells, platelets number or splenomegaly. Taken together these data suggest a decreased activity of red cell antioxidant enzymes in hairy cell leukemia and support a pluripotent stem cell defect of these abnormalities.
Subject: Adult
Aged
Catalase
Erythrocytes
Glutathione
Glutathione Peroxidase
Humans
Leukemia, Hairy Cell
Middle Aged
Superoxide Dismutase
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/8843970
Date Issue: 1996
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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