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Type: Artigo de periódico
Title: Enalapril Does Not Prevent The Myocardial Ischemia Caused By The Chronic Inhibition Of Nitric Oxide Synthesis.
Author: Moreno, H
Piovesan Nathan, L
Pereira Costa, S K
Metze, K
Antunes, E
Zatz, R
De Nucci, G
Abstract: In rats, chronic administration of the nitric oxide (NO) inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) causes arterial hypertension, cardiac hypertrophy and myocardial ischemic alterations such as necrosis and fibrosis. In this study, we evaluated the effect of 8 weeks of treatment with enalapril maleate on cardiac weight and on the development of the histological alterations induced by L-NAME. Enalapril significantly inhibited the development of both arterial hypertension (117.2 +/- 5.8, 161.8 +/- 8.8 and 122.0 +/- 10.6 mm Hg, for control, L-NAME- and L-NAME + enalapril-treated animals, respectively) and left ventricular hypertrophy (1.36 +/- 0.13, 1.60 +/- 0.04 and 1.48 +/- 0.05 mg/g, for control, L-NAME- and L-NAME + enalapril-treated animals, respectively), but had no effect on the myocardial lesions. These findings demonstrate that although the renin-angiotensin system plays a major role in the development of arterial hypertension and cardiac hypertrophy, it does not modulate the ischemia-induced myocardial alterations observed in this model.
Subject: Angiotensin-converting Enzyme Inhibitors
Antihypertensive Agents
Myocardial Ischemia
Ng-nitroarginine Methyl Ester
Nitric Oxide
Organ Size
Rats, Wistar
Rights: fechado
Identifier DOI: 
Date Issue: 1995
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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