Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193845
Type: Artigo de periódico
Title: Oxidative Damage Of Mitochondria Induced By Fe(ii)citrate Or T-butyl Hydroperoxide In The Presence Of Ca2+: Effect Of Coenzyme Q Redox State.
Author: Castilho, R F
Kowaltowski, A J
Meinicke, A R
Vercesi, A E
Abstract: The role of coenzyme Q on the process of mitochondrial membrane damage associated with oxidative stress was studied in a suspension of uncoupled mitochondria exposed to Ca2+ in the presence of Fe(II)citrate or t-butyl hydroperoxide. Reduction of coenzyme Q by succinate was shown to inhibit both inner membrane lipid peroxidation and permeabilization induced by Fe(II)citrate. In contrast, the inner membrane permeabilization induced by Ca2+ alone or Ca2+ plus t-butyl hydroperoxide was potentiated by the presence of succinate. These results support our previous proposition that the mitochondrial damage associated with oxidative stress generated by these pro-oxidants in the presence of Ca2+ is mediated by different mechanisms.
Subject: Animals
Antimycin A
Butylated Hydroxytoluene
Calcium
Ferrous Compounds
Free Radicals
Mitochondria, Liver
Mitochondrial Swelling
Oxidation-reduction
Oxidative Stress
Peroxides
Rats
Rats, Wistar
Succinates
Succinic Acid
Thiobarbituric Acid Reactive Substances
Ubiquinone
Tert-butylhydroperoxide
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/7896171
Date Issue: 1995
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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