Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193822
Type: Artigo de periódico
Title: Factor V Leiden (fvq 506) Is Common In A Brazilian Population.
Author: Arruda, V R
Annichino-Bizzacchi, J M
Costa, F F
Reitsma, P H
Abstract: Resistance to activated protein C (APC) is the most common risk factor in venous thrombosis. A missense mutation in the factor V gene (factor V Leiden) is the molecular basis for this phenotype. Factor V Leiden was previously found in about 20% of unselected patients with thrombosis but also occurred in 3-5% of healthy Dutch controls. In the present study of Brazilian patients with venous thrombosis we also observed a frequency of 20% for this factor. In addition, in healthy Brazilian controls the frequency of the mutation was 2%. These data suggest that factor V Leiden has a similar distribution worldwide irrespective of the ethnic origin of the population.
Subject: Base Sequence
Brazil
Dna
Drug Resistance
Enzyme Activation
Factor V
Gene Frequency
Humans
Molecular Sequence Data
Mutation
Netherlands
Protein C
Thrombophlebitis
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/7604818
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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