Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193811
Type: Artigo de periódico
Title: Effect Of Glucagon On Insulin Receptor Substrate-1 (irs-1) Phosphorylation And Association With Phosphatidylinositol 3-kinase (pi 3-kinase).
Author: Saad, M J
Hartmann, L G
de Carvalho, D S
Galoro, C A
Brenelli, S L
Carvalho, C R
Abstract: In the present study we have examined the levels and phosphorylation state of the insulin receptor and insulin receptor substrate 1 (IRS-1) as well as the association between IRS-1 and phosphatidylinositol 3-kinase (PI 3-kinase) in the liver and muscle of rats treated with glucagon. There was a decrease in the insulin-stimulated receptor and IRS-1 phosphorylation levels which was paralleled by a reduced association between IRS-1 and PI 3-kinase in vivo in the liver and muscle of glucagon-treated rats. These observations suggest that glucagon, probably acting through cAMP, may impair insulin signaling in the three early steps in insulin action after binding.
Subject: Animals
Glucagon
Insulin
Insulin Receptor Substrate Proteins
Liver
Male
Muscle, Skeletal
Phosphatidylinositol 3-kinases
Phosphoproteins
Phosphorylation
Phosphotransferases (alcohol Group Acceptor)
Phosphotyrosine
Rats
Reference Values
Tyrosine
Rights: fechado
Identifier DOI: 
Address: http://www.ncbi.nlm.nih.gov/pubmed/7544300
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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