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|Type:||Artigo de periódico|
|Title:||2'-fluoropolynucleotide-directed Reverse Transcriptase Reactions. Effect Of Homologous Polynucleotides.|
|Author:||Juca, M B|
|Abstract:||Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2'-fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poly(2'-O-methyladenylic acid) (poly(Am)), poly(2'-fluoro-2'-deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2'-fluorinated polynucleotide-directed reverse transcriptase activity.|
|Subject:||Avian Myeloblastosis Virus|
Dose-response Relationship, Drug
Rna-directed Dna Polymerase
Reverse Transcriptase Inhibitors
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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