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Type: Artigo de periódico
Title: 2'-fluoropolynucleotide-directed Reverse Transcriptase Reactions. Effect Of Homologous Polynucleotides.
Author: Juca, M B
Aoyama, H
Abstract: Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2'-fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poly(2'-O-methyladenylic acid) (poly(Am)), poly(2'-fluoro-2'-deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2'-fluorinated polynucleotide-directed reverse transcriptase activity.
Subject: Avian Myeloblastosis Virus
Dose-response Relationship, Drug
Poly A
Poly I
Poly U
Rna-directed Dna Polymerase
Reverse Transcriptase Inhibitors
Templates, Genetic
Rights: fechado
Identifier DOI: 
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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