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|Type:||Artigo de periódico|
|Title:||Biosynthesis Of A Trypanocide By Chromobacterium Violaceum.|
Antonio, R V
Pilli, R A
|Abstract:||Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates. Using 3-indolyl [2-(14)C] and [1-(14)C] acetic acid, it was found that the carboxylic carbon was not eliminated and that indole-3-acetic acid was incorporated intact into the pigment structure. N-Ethyl(5-hydroxy-indol-3-yl)-2-indolylethylamide is also an important metabolic intermediate in the violacein biosynthesis. This is the first report of a metabolic scheme for violacein synthesis which includes an intermediate other than L-tryptophan.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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