Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/193779
Type: Artigo de periódico
Title: Bone Marrow Morphology In Patients With Neutropenia Due To Chronic Exposure To Organic Solvents (benzene): Early Lesions.
Author: Ruiz, M A
Augusto, L G
Vassallo, J
Vigorito, A C
Lorand-Metze, I
Souza, C A
Abstract: The authors present the histological and cytological features of bone marrow (BM) in 152 employees from the steel plant of Cubatão (S. Paulo-Brazil) who presented with neutropenia, due to chronic exposure to benzene and its homologues. All patients were male. Mean age was 35 years. At the time of this study, all patients were removed from risk areas because of the hematological abnormality. BM morphology was characterized by a hypocellular hemopoiesis (82%). Decrease of the granulocytic precursors (86%) was the most outstanding feature. Erythroid and megakaryocytic series were diminished in 40% and 57% of the cases, respectively. Eosinophilia in BM was observed in 71% of the cases. Cell atypias and stromal changes (necrosis, increase in reticulin fibres) were frequent.
Subject: Adult
Benzene
Blood Cell Count
Bone Marrow
Hematopoietic Stem Cells
Humans
Male
Middle Aged
Neutropenia
Time Factors
Rights: fechado
Identifier DOI: 10.1016/S0344-0338(11)80705-3
Address: http://www.ncbi.nlm.nih.gov/pubmed/8058569
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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